Triethylamine → HCID 67316418, compound

Participants

Reaction Steps

Combine 1-(4-(4-fluorophenyl)phthalazin-1-yl)piperidin-4-amine (110 mg, 0.34 mmol), triethylamine (0.14 mL, 1.02 mmol) and dichloromethane (2 mL) at room temperature. Add 4-(trifluoromethyl)-benzoyl chloride (85 mg, 0.41 mmol) to the mixture and stir at room temperature overnight. Concentrate the reaction mixture and purify the resulting residue by flash chromatography (20:5:1. hexane:ethyl acetate: 2 M ammonia in methanol). Add 1 N HCl in diethyl ether to a solution of the isolated product in dichloromethane/methanol and remove the solvents under a stream of nitrogen gas to yield the title compound as a solid (57 mg, 32%). ES/MS m/z 495.2 (M+1).

Provenance & Evidence