Potassium Carbonate → HCID 87353595, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-(benzyloxy)-N-(4-fluorobenzyl)-9,9-dimethyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a]pyrimidine-2-carboxamide (see Example 3, Step 1), K2CO3 (2 eq.) and bromoacetonitrile (2 eq.) in DMF was heated at 70° C. overnight and was then cooled to room temperature. The solvent was removed under reduced pressure and the residue was taken up in EtOAc, washed with brine, dried (Na2SO4) and concentrated to yield the crude nitrile which was used in the next step without further purification. 1H NMR (300 MHz, d6-DMSO) δ 8.9 (t, J=6.2 Hz, 1H), 7.26-7.41 (m, 7H), 7.06 (t, J=8.8 Hz, 2H), 5.06 (s, 2H), 4.41 (d, J=6.2 Hz, 2H), 3.96 (s, 2H), 3.89 (t, J=5.2 Hz, 2H), 3.15 (t, J=5.2 Hz, 2H), 1.53 (s, 6H); MS (ES) C26H26FN5O3 requires 475. Found: 476 (M+H+).

Provenance & Evidence