4-(4-Oxocyclohexylamino)-3-ethoxy-2-methylpyridine → 4-[4-(3-Cyclohexylpropylidene)cyclohexylamino]-3-ethoxy-2-methylpyridine

HRID 1013Notes

Reaction equation

HRID 1013 reaction equation
O=[C:2]1[CH2:7][CH2:6][CH:5]([NH:8][C:9]2[CH:14]=[CH:13][N:12]=[C:11]([CH3:15])[C:10]=2[O:16][CH2:17][CH3:18])[CH2:4][CH2:3]1.[Cl-].[CH:20]1([CH2:26][CH2:27][CH2:28][P+](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1>>[CH:20]1([CH2:26][CH2:27][CH:28]=[C:2]2[CH2:7][CH2:6][CH:5]([NH:8][C:9]3[CH:14]=[CH:13][N:12]=[C:11]([CH3:15])[C:10]=3[O:16][CH2:17][CH3:18])[CH2:4][CH2:3]2)[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 196939434-(4-Oxocyclohexylamino)-3-ethoxy-2-methylpyridineHCID 196940333-Cyclohexylpropyltriphenylphosphonium chloride

Product 1

HCID 196940374-[4-(3-Cyclohexylpropylidene)cyclohexylamino]-3-ethoxy-2-methylpyridineYield 42%

Procedure

Preparation was carried out analogously to Example 27 from 4-(4-oxocyclohexylamino)-3-ethoxy-2-methylpyridine and 3-cyclohexylpropyltriphenylphosphonium chloride. Yield: 42%

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-70baa8bcab424511a56acfca39fce88b
Source dataset
uspto-grants-1998_03
Patent number
US05723450

Reaction notes

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