Propargyl bromide → HCID 87353683, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-(benzyloxy)-N-(4-fluorobenzyl)-9,9-dimethyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a]pyrimidine-2-carboxamide (prepared as described in Example 3, Step 1) (1 eq.), K2CO3 (2 eq.), propargyl bromide (2.5 eq.) in DMF was heated at 45° C. overnight and then cooled at room temperature. The solvent was removed under reduced pressure and the residue was taken up in EtOAc and washed with brine, dried (Na2SO4), filtered and concentrated under reduced pressure to yield the titled acetylene. MS (ES) C27H27FN4O3 requires 474. Found: 475 (M+H+).

Provenance & Evidence