HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → tert-Butyl 4-amino-4-carbamoylpiperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | tert-Butyl 4-(((benzyloxy)carbonyl)amino)-4-carbamoylpiperidine-1-carboxylate | HCID 10714606 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | tert-Butyl 4-amino-4-carbamoylpiperidine-1-carboxylate | HCID 10562199 | 90% |
Reaction Steps
1B (1.0 equivalent) and a catalytic amount of acetic acid in MeOH (0.05M) was passed through H-cube hydrogenator equipped with Pd/C cartridge at 50° C. The methanol in the reaction mixture was then removed under reduced pressure, and the product was washed with cold ether twice to afford the tert-butyl 4-amino-4-carbamoylpiperidine-1-carboxylate (1C, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07981904B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-367907cef00340c4bafce33b32861342 |
| Source note | uspto-grants-2011_07 |