Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1013081생성일: 2026년 10월 25일
Acetic Acid → Tert-butyl 2-(chloromethyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-1-ene-8-carboxylate
https://huagongshe.com/reaction/1013081
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | 1,1,1-Trimethoxy-2-chloroethane | HCID 144702 | — |
| 반응물 | tert-Butyl 4-amino-4-carbamoylpiperidine-1-carboxylate | HCID 10562199 | — |
| 생성물 | Tert-butyl 2-(chloromethyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-1-ene-8-carboxylate | HCID 57908082 | 67% |
반응 단계
1C (0.3M) was added 2-chloro-1,1,1-trimethoxyethane (4.0 equivalents) and acetic acid (2.0 equivalents). The mixture was stirred for 12 hr at 118° C. Solvent was removed under reduced pressure and the residue was purified by crystallization from cold diethyl ether to afford tert-butyl 2-(chloromethyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-1-ene-8-carboxylate (1D, 67%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07981904B2 |
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| 출처 데이터셋 | uspto-grants-2011_07 |
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| ORD ID | ord-233f9b8f83244ebaa8da77b64ee7e9cf |
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| 출처 메모 | uspto-grants-2011_07 |
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