Trifluoroacetic acid methylene chloride → Trifluoroacetic acid

Participants

Reaction Steps

For deprotection, 2A (1.0 equivalent) was dissolved in CH2Cl2 at 0° C., and slowly treated with a 1.6:1 solution of CH2Cl2/TFA (2:1 final ratio, 0.15 M). The reaction was completed in 30 minutes at 0° C. as determined by LCMS analysis. The volatiles were removed under reduced pressure to yield N-((4-oxo-1,3,8-triazaspiro[4.5]dec-1-en-2-yl)methyl)acetamide (2B) as TFA salts which were used without further purification. ESI-MS: m/z 225.1 (M+H)+.

Provenance & Evidence