1,2-Dichloroethane → HCID 46193342, compound

Participants

Reaction Steps

A solution of 3A (1.0 equivalent) in DMF (0.12 M) along with a 2-aminobenzo[b]thiophene-3-carboxylic acid (1.0 equivalent) was treated with EDC (1.0 equivalent), HOBt (1.0 equivalent) and Et3N (2.0 equivalents) at rt. The reaction mixture was stirred until the reaction was complete as determined by LCMS analysis and then partitioned between ethyl acetate and water. Organic layers were washed with brine and dried over Na2SO4, and volatiles removed under reduced pressure. Residue purified by LCMS to afford 8-(2-aminobenzo[b]thiophene-3-carbonyl)-2-(methylthiomethyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one (2B).

Provenance & Evidence