Potassium Cyanide → HCID 44243001, compound

Participants

Reaction Steps

A solution of 6B (1.0 equivalent) in MeOH (0.06M), was slowly added NH4Cl (1.2 equivalents) and 30% aq. NH3OH (0.06M) and stirred at room temperature for 30 minutes. The mixture was cooled at 0° C., and KCN was added in portions. After 12 hrs, 80% of MeOH was removed under reduced pressure, and then replaced MeOH with diethyl ether at 0° C. Filtered crystallized solid and washed crystals with cold diethyl ether twice to afford the 1-(3-(4-amino-4-cyanopiperidine-1-carbonyl)benzo[b]thiophen-2-yl)-3-ethylurea (6, 79%). Two rotamers observed (ratio 1:1).

Provenance & Evidence