Pyridine → HCID 59799037, compound

Participants

Reaction Steps

Under a nitrogen atmosphere, mix 9-bromo-6-hydroxy-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine (6 g, 17.8 mmol), anhydrous pyridine (0.06 mL, 0.72 mmol), 4-(dimethylamino)pyridine (222 mg, 1.8 mmol) and acetic anhydride (30 mL). Heat the mixture at reflux for 8 h and stir at RT for another 8 h Concentrate, dilute the residue in EtOAc, wash with 1 N HCl, and then with saturated aqueous sodium bicarbonate solution. Dry (sodium sulfate) and concentrate to give the title compound that was used in the next step without further purification.

Provenance & Evidence