Potassium Carbonate → HCID 67315890, compound

Participants

Reaction Conditions

Reaction Steps

A solution of the product from example 1, step b (300 mg) was dissolved in DMF and treated with K2CO3 (166 mg, 1.2 mmol) followed by t-butyl bromoacetate (150 μL, 1 mmol). The reaction was heated to 80° C. for 1 h. Additional K2CO3 and t-butyl bromoacetate were added (1 mmol each) and the reaction was heated to 100° C. for 2 h. The reaction was cooled and partitioned between EtOAc and water. The organic layer was washed with water 3 times then dried over MgSO4 and concentrated to give the sub-title compound as a yellow solid. MS: ESI (positive): 397 (M+H).

Provenance & Evidence