Isoxazole, 4-(chloromethyl)-5-methyl-3-phenyl- → {2-Methyl-3-[2-(5-methyl-3-phenyl-isoxazol-4-ylmethyl)-1,1-dioxo-2,3-dihydro-1h-1lambda6-benzo[d]isothiazol-3-yl]-indol-1-yl}-acetic acid

HRID 1013188노트

반응식

HRID 1013188 반응식
C([O:5][C:6](=[O:29])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([CH:17]2[C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=3[S:19](=[O:27])(=[O:26])[NH:18]2)=[C:9]1[CH3:28])(C)(C)C.Cl[CH2:31][C:32]1[C:33]([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)=[N:34][O:35][C:36]=1[CH3:37]>>[CH3:28][C:9]1[N:8]([CH2:7][C:6]([OH:5])=[O:29])[C:16]2[C:11]([C:10]=1[CH:17]1[C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=3[S:19](=[O:27])(=[O:26])[N:18]1[CH2:31][C:32]1[C:33]([C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)=[N:34][O:35][C:36]=1[CH3:37])=[CH:12][CH:13]=[CH:14][CH:15]=2

참가 물질

3

반응물 2

HCID 11052826Isoxazole, 4-(chloromethyl)-5-methyl-3-phenyl-HCID 67317115[3-(1,1-Dioxo-2,3-dihydro-1h-1lambda6-benzo[d]isothiazol-3-yl)-2-methyl-indol-1-yl]-acetic acid tert-butyl ester

생성물 1

HCID 11526569{2-Methyl-3-[2-(5-methyl-3-phenyl-isoxazol-4-ylmethyl)-1,1-dioxo-2,3-dihydro-1h-1lambda6-benzo[d]isothiazol-3-yl]-indol-1-yl}-acetic acid

실험 절차

The title compound was prepared by the method described for example 14 using the product from example 3, step c) and 4-chloromethyl-5-methyl-3-phenyl-isoxazole. MS: ESI (negative): 526 (M−H).

출처 및 근거

ORD 기록
ord-d871a698aa1f41018a32bc5d119fe1e4
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07981912B2

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