2-(Bromomethyl)-1,3-benzothiazole → [3-(2-Benzothiazol-2-ylmethyl-1,1-dioxo-2,3-dihydro-1h-1lambda6-benzo[d]isothiazol-3-yl)-5-methyl-indol-1-yl]-acetic acid

HRID 1013200Notes

Reaction equation

HRID 1013200 reaction equation
C([O:5][C:6](=[O:29])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][C:13]([CH3:17])=[CH:14][CH:15]=2)[C:10]([CH:18]2[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[S:20](=[O:28])(=[O:27])[NH:19]2)=[CH:9]1)(C)(C)C.Br[CH2:31][C:32]1[S:33][C:34]2[CH:40]=[CH:39][CH:38]=[CH:37][C:35]=2[N:36]=1>>[S:33]1[C:34]2[CH:40]=[CH:39][CH:38]=[CH:37][C:35]=2[N:36]=[C:32]1[CH2:31][N:19]1[CH:18]([C:10]2[C:11]3[C:16](=[CH:15][CH:14]=[C:13]([CH3:17])[CH:12]=3)[N:8]([CH2:7][C:6]([OH:5])=[O:29])[CH:9]=2)[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[S:20]1(=[O:27])=[O:28]

Participants

3

Reactant 2

HCID 27762582-(Bromomethyl)-1,3-benzothiazoleHCID 67317704[3-(1,1-Dioxo-2,3-dihydro-1h-1lambda6-benzo[d]isothiazol-3-yl)-5-methyl-indol-1-yl]-acetic acid tert-butyl ester

Product 1

HCID 59753800[3-(2-Benzothiazol-2-ylmethyl-1,1-dioxo-2,3-dihydro-1h-1lambda6-benzo[d]isothiazol-3-yl)-5-methyl-indol-1-yl]-acetic acid

Procedure

The title compound was prepared by the method described for example 14 using the product from example 2, step c) and 2-bromomethyl-benzothiazole. MS: ESI (negative): 502 (M−H).

Sources & evidence

ORD record
ord-25645513715d456a812f0b4b5540bc11
Source dataset
uspto-grants-2011_07
Patent number
US07981912B2

Reaction notes

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