Potassium Hydroxide → HCID 11651418, compound

HRID 1013354Notes

Reaction equation

HRID 1013354 reaction equation
C(OC([N:6]1[CH2:13][CH:12]2[CH:8]([CH2:9][C:10]3[C:16]([Cl:17])=[C:15]([CH3:18])[S:14][C:11]=32)[CH2:7]1)=O)C.[OH-].[K+]>CCO.C(Cl)Cl>[Cl:17][C:16]1[C:10]2[CH2:9][CH:8]3[CH:12]([C:11]=2[S:14][C:15]=1[CH3:18])[CH2:13][NH:6][CH2:7]3

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 131727024HCID 131727024, compound

Product 1

HCID 11651418HCID 11651418, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 6344DichloromethaneSolvent

Procedure

The product of step d) was treated with 40% aqueous KOH in EtOH at 105° C. for 16 hours. The reaction was cooled, diluted with CH2Cl2 and passed through an extrelut column to remove the water. The organic layer was concentrated and the residue purified by preparative LC/MS to give the title compound. MS calculated for C10H12ClNS+H 214, observed 214.

Workup

  1. temperatureThe reaction was cooled
  2. customto remove the water
  3. concentrationThe organic layer was concentrated
  4. customthe residue purified by preparative LC/MS

Sources & evidence

ORD record
ord-e1b72d01aef64e31a8a76be7bdd7968d
Source dataset
uspto-grants-2011_07
Patent number
US07981919B2

Reaction notes

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