HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 1-Benzyl-4-(4,5-dibromo-thiophen-2-yl)-pyrrolidine-3-carboxylic acid trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 1,1-Dimethylethyl 4-(4,5-dibromo-2-thienyl)-1-(phenylmethyl)-3-pyrrolidinecarboxylate | HCID 67207338 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Benzyl-4-(4,5-dibromo-thiophen-2-yl)-pyrrolidine-3-carboxylic acid trifluoroacetate | HCID 67206234 | — |
Reaction Steps
The product of step b) (2.6 g, 5.2 mmol) in CH2Cl2 (25 ml) and trifluoroacetic acid (TFA) (75 ml) was stirred at 22° C. for 16 hours. Next, the solvent was evaporated and toluene (50 ml) was added and subsequently evaporated in vacuo at 40° C. to remove residual TFA. The crude subtitle product was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07981919B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-55593deda0394cd2a40c0c3643d35556 |
| Source note | uspto-grants-2011_07 |