HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 1-Benzyl-4-(4-bromo-thiophen-2-yl)-pyrrolidine-3-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | HCID 67206869 | HCID 67206869 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Benzyl-4-(4-bromo-thiophen-2-yl)-pyrrolidine-3-carbonyl chloride | HCID 86229187 | 100% |
Reaction Steps
A solution of the product from step c) (4.6 g, 12.6 mmol) in CH2Cl2 (63 ml) was treated with DMF (3-5 drops) and oxalyl chloride (2.4 g, 18.9 mmol) for 2 hours. Next, the solvent was evaporated in vacuo to give 4.04 g (100%) of the subtitle compound that was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07981919B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-241caba7a26e49589927f5c152aaff88 |
| Source note | uspto-grants-2011_07 |