Potassium Fluoride → HCID 131729033, compound

Participants

Reaction Conditions

Reaction Steps

Dipyridyl (31 mg, 0.20 mmol), CuI (34 mg, 0.18 mmol) and KF (10 mg, 0.18 mmol) were added to a solution of the product from step b) (78 mg, 0.17 mmol) in 1.6 mL of 1:1 DMF/1-methyl-2-pyrollidinone. The reaction mixture was stirred for 1 hour at 80° C. and then cooled to room temperature. Next, trifluoromethyl trimethylsilane (118 mg, 0.83 mmol) was added and the reaction mixture was heated to 80° C. for 12 hours. The reaction was cooled to room temperature and filtered through a silica plug eluting with CH2Cl2 (10 ml). The organic mixture was washed with brine (2×3 mL), dried with MgSO4, and was concentrated to a dark oil that was purified by preparative LC/MS to give the subtitle compound. MS calculated for C15H17BrF3NO2S +H: 412, observed: 413.

Provenance & Evidence