Tert-Butyl nitrite → HCID 58624929, compound

Participants

Reaction Conditions

Reaction Steps

Tert-butylnitrite (7.09 g, 0.069 mol) was added to the product of step d) (16.8 g, 0.046 mol) dissolved in 200 mL of ethanol followed by the addition of copper diacetate (12.5 g, 0.069 mol). The reaction mixture was heated for one hour at 60° C., cooled to room temperature, diluted with 200 mL of water and extracted with ethyl acetate (3×200 mL). The combined organic extracts were dried (MgSO4) and solvent evaporated in vacuo to give the crude product that was purified by column chromatography (SiO2) using a 5-50% ethylacetate-hexane gradient to afford the subtitle compound (5.8 g, yield: 36%). MS calculated for C18H25NO4S +H: 352, observed: 352.

Provenance & Evidence