Tetrahydrofuran → HCID 57925986, compound

Participants

Reaction Steps

(4-Methoxyphenyl)phosphonic dichloride (2.00 g, 8.89 mmol) was made 0.1 M in 1:1 THF:ether and stirred at −78° C. To this stirring solution vinyl magnesium bromide (17.8 mL, 17.78 mmol, 1M in THF) was added dropwise. The mixture was stirred for 1 h, then quenched with 2M aq. HCl and extracted with DCM (3×). The combined organic extracts were washed with brine, dried (MgSO4) and concentrated to afford the requisite product. MS: cal'd 209 (MH+), exp 209 (MH+)

Provenance & Evidence