Lithium Hydroxide → HCID 57926019, compound

Participants

Reaction Steps

A mixture of methyl 6-[(diethoxyphosphoryl)methyl]nicotinate (108 mg, 0.376 mmol), THF (1.13 mL) and MeOH (0.376 mL) was treated with LiOH (0.376 mL, 3.0M in water, 1.13 mmol) and stirred for 2 h. The mixture was concentrated to a white residue used crude in the next step. 1H NMR (DMSO-d6, 600 MHz) δ 8.95 (m, 1H), 8.22 (m, 1H), 7.48 (m, 1H), 3.96 (dt, J=15.3, 7.0 Hz, 4H), 3.53 (d, J=22.0 Hz, 2H), 1.15 (t, J=7.0 Hz, 3H). MS: cal'd 274 (MH+), exp 274 (MH+).

Provenance & Evidence