反应详情

To a stirring solution of 4-[(dimethoxy-phosphoryl)-fluoro-methyl]-benzoic acid benzyl ester (76 mg, 0.216 mmol) in MeOH (0.21M) was added 20 mol % Pd on Carbon (0.043 mmol). The resulting mixture was degassed with alternating vacuum and hydrogen gas (4×), then stirred under a hydrogen atmosphere (1 atm) at ambient temperature for 18 hours. The reaction mixture was filtered through a nylon syringe filter and concentrated in vacuo to give the title compound: MS: cal'd 263 (MH+), exp 263 (MH+)

1. customThe resulting mixture was degassed
2. filtrationThe reaction mixture was filtered through a nylon syringe
3. filtrationfilter
4. concentrationconcentrated in vacuo