HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 4-({[2-[(tert-Butoxycarbonyl)amino]-5-(2-thienyl)phenyl]amino}carbonyl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl 4-[({2-[(tert-butoxycarbonyl)amino]-5-thien-2-ylphenyl}amino)carbonyl]benzoate | HCID 57607810 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-({[2-[(tert-Butoxycarbonyl)amino]-5-(2-thienyl)phenyl]amino}carbonyl)benzoic acid | HCID 57925915 | — |
Reaction Steps
To a solution of methyl 4-({[2-[(tert-butoxycarbonyl)amino]-5-(2-thienyl)phenyl]amino}carbonyl)benzoate (3.20 g, 7.07 mmol) in 1:1:2 H2O:MeOH:THF (80 mL) was added LiOH (1.20 g, 50.1 mmol). The reaction was stirred at room temperature for 18 h, diluted with EtOAc, washed with 2 N HCl, dried (Na2SO4), and evaporated to give the desired product as a red solid. MS: cal'd 461 (MNa+), exp 461 (MNa+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07981874B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-27baf62019a04014b3aa999465614150 |
| Source note | uspto-grants-2011_07 |