Water → HCID 57925845, compound

Participants

Reaction Steps

2-(Dimethylphosphoryl)ethanamine hydrochloride (393 mg, 2.493 mmol), tert-butyl (3-{[4-(bromomethyl)benzoyl]amino}biphenyl-4-yl)carbamate (400 mg, 0.831 mmol), and DIEA (581 μl, 3.32 mmol) were combined in DMF (8 mL) and water (0.50 mL) and stirred at 60° C. overnight. The solution was diluted with saturated NaHCO3 and extracted with EtOAc (4×). The combined organics were dried (MgSO4), evaporated, and purified by reverse phase HPLC (25-95% MeCN/water w/0.025% TFA). Product fractions were neutralized with saturated NaHCO3, extracted with EtOAc (2×), dried (MgSO4), and evaporated to give a colorless solid.

Provenance & Evidence