Trifluoroacetic acid → 4-[2-(4-Ethyl-4-oxido-1,4-azaphosphinan-1-yl)-2-oxoethyl]benzoic acid

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Reaction Steps

tert-Butyl 4-[2-(4-ethyl-4-oxido-1,4-azaphosphinan-1-yl)-2-oxoethyl]benzoate (270 mg, 0.739 mmol) was dissolved in CH2Cl2 (8 mL) and TFA (2 mL) and stirred at room temperature for 2 h. The solution was concentrated to dryness, redissolved in MeOH, and concentrated again to give the product as a colorless gum that was carried on without purification. MS: cal'd 310 (MH+), exp 310 (MH+).

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