HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1013534Generated: October 26, 2026
Trimethyl phosphite → Dimethyl {[({[4-({[2-[(tert-butoxycarbonyl)amino]-5-(2-thienyl)phenyl]amino}carbonyl)benzyl]amino}carbonyl)oxy]methyl}phosphonate
https://huagongshe.com/reaction/1013534
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trimethyl phosphite | HCID 8472 | — |
| Reactant | Chloromethyl [4-({[2-[(tert-butoxycarbonyl)amino]-5-(2-thienyl)phenyl]amino}carbonyl)benzyl]carbamate | HCID 57925931 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Dimethyl {[({[4-({[2-[(tert-butoxycarbonyl)amino]-5-(2-thienyl)phenyl]amino}carbonyl)benzyl]amino}carbonyl)oxy]methyl}phosphonate | HCID 57925842 | — |
Reaction Steps
Chloromethyl [4-({[2-[(tert-butoxycarbonyl)amino]-5-(2-thienyl)phenyl]amino}carbonyl)benzyl]carbamate (0.96 g, 1.860 mmol) and trimethyl phosphite (1 ml, 8.48 mmol) were combined in a microwave vial. The vial was capped and the reaction was allowed to heat for 3.5 hours at 100° C. The reaction was cooled and diluted with dichloromethane. The residue was purified by column chromatography on silica gel eluting with EtOAc/hexane. MS: calc'd 490 (MH+-Boc), exp 490 (MH+-Boc).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07981874B2 |
|---|
| Source dataset | uspto-grants-2011_07 |
|---|
| ORD ID | ord-07937bf38cb34f0db14ef02f6998cb5e |
|---|
| Source note | uspto-grants-2011_07 |
|---|
