Water → HCID 46890322, compound

Participants

Reaction Steps

To a stirred solution of 1-[(R)-6-(3-fluoro-phenylsulfanyl)-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl]-azetidin-3-ol (0.08 g, 0.23 mmol) in MeOH (4 mL) was added a solution of OXONE™ (0.307 g, 0.5 mmol) in 2.5 mL water. The reaction mixture was stirred at room temperature for 36 hours. The mixture was taken up in EtOAc, and the organic layer was washed with 1.5 M aqueous sodium carbonate, dried (MgSO4), filtered and concentrated under reduced pressure. The residue was purified by preparative TLC (hexanes/EtOAc/MeOH 5:4:1 to give 0.06 g of 1-[(R)-6-(3-Fluoro-benzenesulfonyl)-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl]-azetidin-3-ol, MS M+H=376.

Provenance & Evidence