HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1013763Generated: October 30, 2026
Potassium Phosphate, Tribasic → 5-Methoxy-N-(4-(7-methoxy-1,5-naphthyridin-4-yloxy)phenyl)pyridazin-3-amine
https://huagongshe.com/reaction/1013763
Participants
| Role | Name | HCID | Charge |
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| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Reactant | 3-Chloro-5-methoxypyridazine | HCID 10975612 | — |
| Reactant | 4-(7-Methoxy-1,5-naphthyridin-4-yloxy)benzenamine | HCID 44185106 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-Methoxy-N-(4-(7-methoxy-1,5-naphthyridin-4-yloxy)phenyl)pyridazin-3-amine | HCID 59427303 | — |
Reaction Steps
A pyrex reaction tube was charged with potassium phosphate (88 mg, 415 μmol), Pd2dba3 (16 mg, 17 mmol), Xantphos (22 mg, 38 mmol), 4-(7-methoxy-1,5-naphthyridin-4-yloxy)benzenamine (92 mg, 346 μmol), 3-chloro-5-methoxypyridazine (50 mg, 346 μmol), and toluene (1 mL). The tube was purged with argon, sealed, and the mixture was heated at 100° C. for 4 h. LCMS showed complete conversion to desired product. The mixture was then concentrated and purified by silica gel chromatography using 0 to 60% (90/10/1 DCM/MeOH/ammonium hydroxide) in DCM. MS: M+H+=376.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07981891B2 |
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| Source dataset | uspto-grants-2011_07 |
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| ORD ID | ord-23d258c4d60d4f1482a94be58e7bebec |
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| Source note | uspto-grants-2011_07 |
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