HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1013777Generated: October 30, 2026
1,1-Dichloroethane → 8-Chloro-1,5-naphthyridin-3-ol
https://huagongshe.com/reaction/1013777
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,1-Dichloroethane | HCID 6365 | — |
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | 8-Chloro-3-methoxy-1,5-naphthyridine | HCID 59427340 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 8-Chloro-1,5-naphthyridin-3-ol | HCID 135743576 | — |
Reaction Steps
A pressure-resistant vial was charged with 8-chloro-3-methoxy-1,5-naphthyridine (1200 mg, 6166 mmol), boron tribromide (6412 μl, 67825 μmol) and dichloroethane (10277 μl, 6166 μmol). The vessel was sealed and the mixture was stirred at 60° C. for 16 h. The reaction mixture was carefully diluted with DCM, and the solids were filtered.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07981891B2 |
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| Source dataset | uspto-grants-2011_07 |
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| ORD ID | ord-7907c6dbcc274dfb9d49353ae26e8dff |
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| Source note | uspto-grants-2011_07 |
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