m-Chloroperbenzoic acid → HCID 59427316, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-(4-fluorophenyl)-N-(4-(7-methoxy-1,5-naphthyridin-4-ylthio)phenyl)phthalazin-1-amine (29 mg, 0.057 mmol) in CH2Cl2(2 mL) and CHCl3(3 mL) at −78° C. was added mCPBA, 77% (14 mg, 0.080 mmol) in one portion. After 1 hr, the mixture was slowly warmed to 0° C. and stirred for an additional 15 min. The solution was diluted with CH2Cl2 and washed with 10% Na2S2O4 and saturated aqueous NaHCO3. After drying the organic fraction with Na2SO4, the solvent was removed in vacuo and the residue purified by silica gel chromatography using 100% CH2Cl2 to 8% MeOH:CH2Cl2 with 1% NH4OH to afford 4-(4-fluorophenyl)-N-(4-(7-methoxy-1,5-naphthyridin-4-ylsulfinyl)phenyl)phthalazin-1-amine (18 mg, 60% yield) as a light yellow solid. MS: M+H+=522. 1.

Provenance & Evidence