反应详情

Heat a solution of 2-chloro-4-methoxy-1-methyl-benzene (2.0 g, 13 mmol), N-bromosuccinimide (2.7 g, 15 mmol), and benzoyl peroxide (50 mg) in CCl4 (50 mL) to reflux and stir for 3 hr. Cool the reaction to room temperature and quench with water. Extract the aqueous with CH2Cl2, dry over MgSO4, and filter. Remove the solvent to afford 3.0 g (98%) of the desired product.

1. temperatureto reflux
2. temperatureCool
3. customthe reaction to room temperature
4. customquench with water
5. extractionExtract the aqueous with CH2Cl2
6. dry with materialdry over MgSO4
7. filtrationfilter
8. customRemove the solvent