HCID 178418361, compound → HCID 178516680, compound

Participants

Reaction Steps

Dissolve (3R,5S)-3-(4-Benzyloxy-2,6-dichloro-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one (Example 35) (8.79 g, 18.7 mmol) in absolute ethanol (60 mL), treat with 20% Pd(OH)2 (6.0 g) and stir at 30 psi hydrogen pressure. After 6 h, ESMS shows starting material consumed and product formed. Remove the catalyst by filtration, rinse with ethanol and evaporate to a dark foam. Filtration through 50 g SCX mega-bond elut using 95:5 CH2Cl2/MeOH followed by 95:5 CH2Cl2/7.0 M NH3/MeOH yields 5.6 g (79%) as an amorphous solid MS (m/z): 380 (M+1)

Provenance & Evidence