反应详情

Treat a solution of 4-Benzyloxy-2,6-dimethyl-benzaldehyde (6.4 g, 27 mmol) in Methanol (60 mL) with Sodium borohydride (0.82 g, 22 mmol). Stir the reaction for 1 hr at room temperature. Quench the reaction with a saturated solution of sodium bicarbonate in water and extract with Et2O. Wash the organic with brine, dry over MgSO4, and filter. Remove the solvent to afford 6.3 g (97%) of product. 1H NMR (d6-CDCl3) δ 7.31-7.43 (m, 5H), 6.65 (s, 2H), 5.01 (s, 2H), 4.66 (s, 2H), 2.38 (s, 6H).

1. customthe reaction for 1 hr at room temperature
2. customQuench
3. customthe reaction with a saturated solution of sodium bicarbonate in water
4. extractionextract with Et2O
5. washWash the organic with brine
6. dry with materialdry over MgSO4
7. filtrationfilter
8. customRemove the solvent