Dichloromethane → HCID 178515644, compound

Participants

Reaction Steps

Cool a solution of 3-(2-Chloro-4-methoxy-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one (3.0 g, 8.3 mmol) in dichloroethane (100 mL) to −78° C. Treat the solution with 1.0M Boron tribromide in CH2Cl2 (46 mL, 46 mmol) and allow the reaction to warm to room temp and stir for 4 hr. Then, cool the reaction to 0° C. and quench with water. Extract the organic with CHCl3, wash with brine, dry over MgSO4, filter, and remove the solvent. Purify the crude by silica gel column chromatography using 10% EtOH in CHCl3 to elute the pure product. Remove the solvent to afford 2.24 g (78%) of product. MS (m/e): 364 (M+1).

Provenance & Evidence