反应详情

Using the general procedure described above, the reaction of 6 (80 mg, 0.26 mmol) and 4-methoxyaniline (244 mg, 1.98 mmol) was run for 18 hours, to provide 52 mg of 8 as a white solid in 51% yield, TLC Rf 0.55 (chloroform-methanol 15:1); mp 266.8-267° C.; 1H NMR (DMSO-d6) δ 1.23 (s, 9H, C(CH3)3), 3.75 (s, 3H, OCH3), 6.88-8.26 (m, 8H, Ar—H), 8.55 (s, 1H, 4-NH, exch), 9.41 (s, 1H, 2-NH, exch), 11.79 (s, 1H, 9-NH, exch). Anal. Calculated (C22H23N5O2, 0.4 H2O): C, 66.61; H, 6.04; N, 17.65. Found: C, 66.61; H, 6.00; N, 17.37.