反应详情

Using the general procedure described above, the reaction of 6 (180 mg, 0.59 mmol) and 4-methoxy-N-methylaniline (612 mg, 4.46 mmol) was run for 72 hours, to provide 109 mg of 9 as brown crystals in 45% yield, TLC Rf 0.62 (chloroform-methanol 15:1); mp 248.2-249° C.; 1H NMR (DMSO-d6) δ 1.26 (s, 9H, C(CH3)3), 3.61 (s, 3H, OCH3), 3.74 (s, 3H, NCH3), 5.76-7.29 (m, 8H, Ar—H), 9.49 (s, 1H, 2-NH, exch), 11.81 (s, 1H, 9-NH, exch). Anal. Calculated (C23H25N5O2. 0.55 CH3OH): C, 67.16; H, 6.51; N, 16.63. Found: C, 67.33; H, 6.49; N, 16.28.