反应详情

A solution of 298 mg (0.612 mmoles) of the purified N-{4-[4-(benzyloxy)-3-chloroanilino]-3-cyano-7-ethoxy-6-quinolinyl}acetamide (example 6) and 97 mg (1.73 mmoles) of potassium hydroxide in 10 ml of methanol was stirred and refluxed for 60 hours. On cooling a solid formed. This mixture was poured onto ice, and the resulting solid was filtered and washed with water. On drying, 242 mg of the title compound was obtained.

1. temperaturerefluxed for 60 hours
2. temperatureOn cooling a solid
3. customformed
4. additionThis mixture was poured onto ice
5. filtrationthe resulting solid was filtered
6. washwashed with water
7. customOn drying