Methylamine tetrahydrofuran → 1-(4-Chloro-2-cyanophenyl)-3-methylurea

HRID 1014060Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:17])OC2C=CC=CC=2)=[C:4]([C:18]#[N:19])[CH:3]=1.O1CCCC1.[CH3:25][NH2:26]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:26][CH3:25])=[O:17])=[C:4]([C:18]#[N:19])[CH:3]=1

Participants

Reactant 2

HCID 66615946Methylamine tetrahydrofuran

HCID 66877344Phenyl (4-chloro-2-cyanophenyl)carbamate

Product 1

HCID 668774621-(4-Chloro-2-cyanophenyl)-3-methylurea

Procedure

(Step 1) Using phenyl (4-chloro-2-cyanophenyl)carbamate obtained in Example 47, Steps 1 and 2N methylamine tetrahydrofuran solution, and in the same manner as in Example 47, Step 2, 1-(4-chloro-2-cyanophenyl)-3-methylurea was obtained.

Sources & evidence

ORD record: ord-4b1ffee93512476d80af56bd6cf37371
Source dataset: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07982044B2

Reaction notes

Loading…