Phenyl chloroformate → 2'-(Phenoxycarbonylaminomethyl)biphenyl-2-carboxylic acid (3-methylbutyl)amide

HRID 1014083Notes

Reaction equation

HRID 1014083 reaction equation
[CH3:1][CH:2]([CH3:22])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[C:9]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH2:20][NH2:21])=[CH:10][CH:11]=[CH:12][CH:13]=1)=[O:7].Cl[C:24]([O:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)=[O:25]>>[CH3:1][CH:2]([CH3:22])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[C:9]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH2:20][NH:21][C:24]([O:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[O:25])=[CH:10][CH:11]=[CH:12][CH:13]=1)=[O:7]

Participants

3

Reactant 2

HCID 15891Phenyl chloroformateHCID 673161092'-Aminomethylbiphenyl-2-carboxylic acid (3-methylbutyl)amide

Product 1

HCID 99317322'-(Phenoxycarbonylaminomethyl)biphenyl-2-carboxylic acid (3-methylbutyl)amide

Procedure

From 0.34 mmol of 2′-aminomethylbiphenyl-2-carboxylic acid ( 3-methylbutyl)amide (precursor 5 c) and phenyl chloroformate, according to the general working procedure followed by extraction with EA and purification by flash chromatography 55 mg of 2′-(phenoxycarbonylaminomethyl)biphenyl-2-carboxylic acid (3-methylbutyl)amide were obtained as a resin. MS (ES+): m/e=417 (M+1).

Workup

  1. extractionfollowed by extraction with EA and purification by flash chromatography 55 mg of 2′-(phenoxycarbonylaminomethyl)biphenyl-2-carboxylic acid (3-methylbutyl)amide
  2. customwere obtained as a resin

Sources & evidence

ORD record
ord-e968d66fddd442af86b5da134bccc6d8
Source dataset
uspto-grants-2011_07
Patent number
US07982045B2

Reaction notes

Loading…