HCID 86634555, compound → HCID 15940236, compound

Participants

Reaction Steps

1-[3-cyclopentyl-2-({formyl[(phenylmethyl)oxy]amino}methyl)propanoyl]-N-[(4-fluorophenyl)carbonyl]-L-prolinamide (0.34 mmol, 180 mg) was dissolved in MeOH (3 mL) and the solution was degassed. 10% Pd/C or Pd/BaSO4 (36 mg) was added and the suspension was charged with H2 via balloon. The reaction was stirred under H2 atmosphere for 1 hour, then filtered and concentrated to provide 1-((2R)-3-cyclopentyl-2-{[formyl(hydroxy)amino]methyl}propanoyl)-N-[(4-fluorophenyl)carbonyl]-L-prolinamide (Example 1) in quantitative yield.

Provenance & Evidence