HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → HCID 20430311, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Acryloyl chloride | HCID 13140 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Bromoacetyl chloride | HCID 89602 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 20430311 | HCID 20430311 | — |
Reaction Steps
Intermediate XVI is subjected to subsequent acylation with an acylating agent, e.g. α-bromoacetyl chloride, acryloyl chloride, or an amino acid, with coupling reagents, e.g. HATU, DMAP, and base, e.g. PS-DIPEA, and solvent, e.g. THF. The acylating agent may be reacted with an appropriate amine base, e.g. Me2NH (with solvent, e.g. THF), and the product then reduced (see reduction of IVa, scheme 4) to provide anilino indoline tails IVx.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07981903B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-9d2eea0524b0446e86eb8dde3a266699 |
| Source note | uspto-grants-2011_07 |