Hydrazine → HCID 59441910, compound

Participants

Reaction Steps

In a manner analgous to the hydrazine-mediated reduction of Intermediate B1, 4-[1-(1-methylethyl)-1,2,3,6-tetrahydro-4-pyridinyl]-2-(methyloxy)aniline (1.60 g, 90% yield) was prepared from 1-(1-methylethyl)-4-[3-(methyloxy)-4-nitrophenyl]-1,2,3,6-tetrahydropyridine (2.0 g, 7.17 mmol). 1H NMR (400 MHz, CDCl3) δ ppm 1.12 (d, J=6.6 Hz, 6 H), 2.54 (s, 2 H), 2.73 (t, J=5.5 Hz, 2 H), 2.79 (dt, J=12.9, 6.6 Hz, 1 H), 3.24 (d, J=3.3 Hz, 2 H), 3.77 (s, 2 H), 3.85 (s, 3 H), 5.94 (s, 1 H), 6.65 (d, J=8.1 Hz, 1H), 6.80-6.86 (m, 2 H).

Provenance & Evidence