Nitric Acid → HCID 59442114, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-methyl-6-(methyloxy)-3,4-dihydro-1(2H)-isoquinolinone (5 g, 26.17 mmol) in H2SO4(2.17 mL) was added HNO3 (1.95 g, 31.4 mmol) dropwise at −20° C. The mixture was stirred for 2 h at −20° C. The reaction was diluted with water and the aqueous layer was extracted with dichloromethane. The combined organic layer was concentrated under reduced pressure to afford 2-methyl-6-(methyloxy)-7-nitro-3,4-dihydro-1(2H)-isoquinolinone (4.7 g, 75.8%).

Provenance & Evidence