Potassium Carbonate → HCID 59441728, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-(methyloxy)-6-nitro-2,3-dihydro-1H-indole (0.7 g, 3.61 mmol) in THF (100 mL) was added 2-chloro-N,N-dimethylacetamide (1.11 g, 10.8 mmol), and potassium carbonate (2.98 g, 21.6 mmol). After heating at 65° C. for 4 days, the reaction was diluted with ethyl acetate (100 mL) and washed with water (100 mL). The organic layer was separated, adsorbed onto silica gel, and purified by column chromatography (DCM to 2% MeOH/DCM) to provide N,N-dimethyl-2-[5-(methyloxy)-6-nitro-2,3-dihydro-1H-indol-1-yl]acetamide (0.16 g, 16%). ESIMS (M+H)+=280.

Provenance & Evidence