HCID 59441728, compound → HCID 59441997, compound

Participants

Reaction Steps

A solution of N,N-dimethyl-2-[5-(methyloxy)-6-nitro-2,3-dihydro-1H-indol-1-yl]acetamide (0.16 g, 1.72 mmol) in absolute ethanol (50 mL) and ethyl acetate (5 mL) was hydrogenated overnight at 45 psi with catalytic 10% Pd/C. The catalyst was removed by vacuum filtration through a celite pad which was rinsed with methanol. The filtrate was concentrated under reduced pressure and dried under high vacuum to provide 2-[6-amino-5-(methyloxy)-2,3-dihydro-1H-indol-1-yl]-N,N-dimethylacetamide. This was then carried forward without any further purification.

Provenance & Evidence