2-Amino-6-methylbenzamide → 2-({2-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)-6-methylbenzamide

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Reaction Steps

Using General Protocol II and starting with 2,4-dichloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine (2.79 g, 8.2 mmol) and 2-amino-6-methylbenzamide (0.830 g, 5.46 mmol), 2-({2-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)-6-methylbenzamide was isolated as a yellow solid (0.960 g, 38% yield); 1H NMR (400 MHz, DMSO-d6) δ ppm 2.32 (s, 3 H), 2.36 (s, 3 H), 6.49 (s, 1 H), 7.18-7.24 (m, 2 H), 7.30 (s, 1 H), 7.44-7.47 (m, 4 H), 7.56 (d, J=4.03 Hz, 1 H), 7.95 (d, J=8.43 Hz, 2 H).

Provenance & Evidence