2-Amino-4,5-dimethoxybenzamide → HCID 86644187, compound

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Reaction Steps

Using General Protocol II and starting with 2,4-dichloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine (3.0 g, 8.8 mmol) and 2-amino-4,5-bis(methyloxy)benzamide (3.7 g, 18.9 mmol), 2-({2-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)-4,5-bis(methyloxy)benzamide was isolated as a white solid (2.75 g, 62% Yield); 1H NMR (400 MHz, DMSO-d6) δ ppm 2.34 (s, 3 H), 3.77 (s, 3 H), 3.80 (s, 3 H), 6.60 (d, J=3.85 Hz, 1 H), 7.38 (s, 1 H), 7.44 (d, J=8.61 Hz, 2 H), 7.62 (s, 1 H), 7.71 (d, J=4.03 Hz, 1 H), 7.95 (d, J=8.42 Hz, 2 H), 8.21 (s, 1 H), 8.32 (s, 1 H), 12.70 (s, 1 H)

Provenance & Evidence