211374-80-0 → HCID 86644191, compound

Participants

Reaction Steps

Using General Protocol II and starting with 2,4-dichloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine (3.0 g, 8.8 mmol) and 2-amino-4,5-difluorobenzamide (4.15 g, 23.9 mmol), 2-({2-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)-4,5-difluorobenzamide was isolated as a white solid (1.80 g, 43% Yield); 1H NMR (400 MHz, DMSO-d6) δ ppm 2.34 (s, 3H), 6.67 (d, J=4.03 Hz, 1 H), 7.46 (d, J=8.61 Hz, 2 H), 7.76 (d, J=4.03 Hz, 1 H), 7.92-8.01 (m, 4 H), 8.35 9s, 1 H), 8.55 (dd, J=13.55, 7.69 Hz, 1 H), 12.50 (s, 1 H).

Provenance & Evidence