2-Amino-4-chlorobenzamide → HCID 86644193, compound

Participants

Reaction Steps

Using General Protocol II and starting with 2,4-dichloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine (3.0 g, 8.8 mmol) and 2-amino-4-chlorobenzamide (3.0 g, 17.6 mmol), 4-chloro-2-({2-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)benzamide was isolated as a yellow solid (0.650 g, 16% Yield); 1H NMR (400 MHz, DMSO-d6) δ ppm 2.36 (s, 3 H), 6.68 (d, J=4.03 Hz, 1 H), 7.23 (dd, J=8.51, 2.10 Hz, 1 H), 7.47 (d, J=8.23 Hz, 2 H), 7.79 (d, J=4.03 Hz, 1 H), 7.87 (d, J=8.42 Hz, 1 H), 7.91 (s, 1 H), 7.98 (d, J=8.42 Hz, 2 H), 8.41 (s, 1 H), 8.66 (d, J=2.20 Hz, 1 H), 12.65 (s, 1 H).

Provenance & Evidence