Sodium Hydroxide → HCID 178493036, compound

HRID 1014439Notes

Reaction equation

HRID 1014439 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[C:7]([NH:12][C:13]2[C:14]3[CH:37]=[CH:36][N:35](S(C4C=CC(C)=CC=4)(=O)=O)[C:15]=3[N:16]=[C:17]([NH:19][C:20]3[CH:25]=[CH:24][C:23]([N:26]4[CH2:31][CH2:30][O:29][CH2:28][C@@H:27]4[CH3:32])=[CH:22][C:21]=3[O:33][CH3:34])[N:18]=2)[C:3]=1[C:4]([NH2:6])=[O:5].[OH-].[Na+]>O1CCOCC1>[F:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[C:7]([NH:12][C:13]2[N:18]=[C:17]([NH:19][C:20]3[CH:25]=[CH:24][C:23]([N:26]4[CH2:31][CH2:30][O:29][CH2:28][C@@H:27]4[CH3:32])=[CH:22][C:21]=3[O:33][CH3:34])[NH:16][C:15]3=[N:35][CH:36]=[CH:37][C:14]=23)[C:3]=1[C:4]([NH2:6])=[O:5]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67317374HCID 67317374, compound

Product 1

HCID 178493036HCID 178493036, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
120 °C

Procedure

2,4-difluoro-6-({2-{[4-[(3S)-3-methyl-4-morpholinyl]-2-(methyloxy)phenyl]amino}-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)benzamide (200 mg, 0.301 mmol) was suspended in a mixture of dioxane (10 mL) and aqueous 2.0N NaOH (5 mL) and stirred rapidly under microwave heating (120° C.) for 10 minutes.

Sources & evidence

ORD record
ord-54f680f0f519475cbc80424c6c252b09
Source dataset
uspto-grants-2011_07
Patent number
US07981903B2

Reaction notes

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