Ammonium Hydroxide → HCID 178457330, compound

Participants

Reaction Steps

In a manner analogous to that described for Example 165, 5-chloro-8-fluoro-3-[(4-methylphenyl)sulfonyl]pyrrolo[2′,3′:4,5]pyrimido[6,1-b]quinazolin-7(3H)-one hydrogen chloride (0.40 g, 0.90 mmol), 27% aqueous ammonium hydroxide, and 5-(methyloxy)-1-{[methyl(propyl)amino]acetyl}-2,3-dihydro-1H-indol-6-amine (0.30 g, 1.1 mmol) and isolated as a yellow solid (0.13 g); 1H NMR (400 MHz, DMSO-d6) δ ppm 0.81 (t, J=7.33 Hz, 3 H), 1.41 (q, J=7.14 Hz, 2H),2.20 (s, 3 H), 2.34 (t, J=7.05 Hz, 2H),3.09 (t, J=8.06 Hz, 2 H), 3.21 (s, 2H), 3.74 (s, 3 H), 4.18 (t, J=8.24 Hz, 2 H), 6.20 (s,1 H), 6.86 (t, J=9.61 Hz, 1H), 6.93 (s, 2H),7.30 (m, 1 H), 7.58 (s, 1H), 8.00 (s,1H), 8.09 (s,1H),8.51 (d, J=8.42 Hz, 1H), 8.59 (s, 1 H), 10.53 (s, 1 H), 11.28 (s, 1 H); ESIMS (M+H)+=547.

Provenance & Evidence